Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease.
Yildirim F*, Ng CW, Kappes V, Ehrenberger T, Rigby SK, Stivanello V, Gipson TA, Soltis AR, Vanhoutte P, Caboche J, Housman DE*, Fraenkel E*
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24840-24851. | *Co-corresponding author
Synaptic control of DNA-methylation involves activity-dependent degradation of DNMT3a1 in the nucleus.
Gonca Bayraktar, PingAn Yuanxiang, Guilherme M Gomes, Aessandro D Confettura, Syed A Raza, Oliver Stork, Shoji Tajima, Ferah Yildirim, Michael R. Kreutz
BioRxiv. 2019 April. doi: https://doi.org/10.1101/602151
Antidepressive effects of targeting ELK-1 signal transduction.
Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET
Nat Med. 2018 May;24(5):591-597
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
HD iPSC Consortium
Nat Neurosci2017;20:648-660
Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia.
Schweizer S, Harms C, Lerch H, Flynn J, Hecht J, Yildirim F, Meisel A, Märschenz S.,
J Cereb Blood Flow Metab. 2015 Oct;35(10):1640-7
Histone Acetylation and CREB Binding Protein Are Required for Neuronal Resistance against Ischemic Injury.
Yildirim F, Ji S, Kronenberg G, Barco A, Olivares R, Benito E, Dirnagl U, Gertz K, Endres M, Harms C, Meisel A.,
PLoS One. 2014; 9(4): e95465.
Targeting H3K4 trimethylation in Huntington disease.
Vashishtha M*, Ng CW*, Yildirim F*, Gipson TA, Kratter IH, Bodai L, Song W, Lau A, Labadorf A, Vogel-Ciernia A, Troncosco J, Ross CA, Bates GP, Krainc D, Sadri-Vakili G, Finkbeiner S, Marsh JL, Housman DE, Fraenkel E, Thompson LM.,
Proc Natl Acad Sci U S A. 2013; 110(32): E3027-36. doi: 10.1073/pnas.1311323110. Epub 2013 Jul 19. *co-first authorship
Extensive changes in DNA methylation are associated with expression of mutant huntingtin.
Ng CW, Yildirim F, Yap YS, Dalin S, Matthews BJ, Velez PJ, Labadorf A, Housman DE, Fraenkel E.,
Proc Natl Acad Sci U S A. 2013; 110(6): 2354-9. doi: 10.1073/pnas.1221292110. Epub 2013 Jan 22.
Poly-glutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1.
Riva L, Koeva M, Yildirim F, Dinesh D, Mazor T, Duennwald ML, Fraenkel E.,
Journal of Huntington’s Disease. 2012; 1: 33-45.
Impact of actin filament stabilization on adult hippocampal and olfactory bulb neurogenesis.
Kronenberg G, Gertz K, Baldinger T, Kirste I, Eckart S, Yildirim F, Ji S, Heuser I, Schröck H, Hörtnagl H, Sohr R, Djoufack PC, Jüttner R, Glass R, Przesdzing I, Kumar J, Freyer D, Hellweg R, Kettenmann H, Fink KB, Endres M.,
J Neurosci. 2010; 30(9): 3419-31.
Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury.
Yildirim F, Gertz K, Kronenberg G, Harms C, Fink KB, Meisel A, Endres M.,
Exp Neurol. 2008; 210: 531-42.
Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation.
Meisel A*, Harms C*, Yildirim F*, Bosel J, Kronenberg G, Harms U, Fink KB, Endres M.,
J Neurochem. 2006; 98: 1019-31. *co-first authorship